Research papers


Baillet, J., Desvergnes, V., Hamoud, A., Latxague, L., Barthélémy, P. (2018) Lipid and Nucleic Acid Chemistries: Combining the Best of Both Worlds to Construct Advanced Biomaterials. Advanced  Materials, 1705078.  DOI: 10.1002/adma.201705078


Hamoud, A., Barthélémy, P. Desvergnes, V.  (2018) Organocatalyzed Stetter reaction as a bio-inspired tool for the synthesis of nucleic acids-based bioconjugates. Organic & Biomolecular Chemistry, DOI: 10.1039/C8OB00192H


Latxague, L., Gaubert, A., Barthélémy, P. (2018) Recent advances in the chemistry of glycoconjugate amphiphiles. Molecules, 23, 89; doi:10.3390/molecules23010089


Benizri, S., Ferey, L., Alies, B., Mebarek N., Vacher, G., Appavoo, A., Gaudin, K., Barthélémy, P. (2018) Nucleoside-Lipid-Based Nanocarriers for Sorafenib Delivery. Nanoscale Research Letters. DOI 10.1186/s11671-017-2420-2


Brune, A. Gissot, R. Delzor and P. Barthelemy, (2017), “Controlling G-quadruplex formation via lipid modification of oligonucleotide séquences” Chem. Commun., DOI: 10.1039/C7CC05693A.


Ramin MA, Latxague L, Sindhu KR, Chassande O, Barthélémy P, (2017) “Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials” Biomaterials doi: 10.1016/j.biomaterials.2017.08.034.


Prévot G, Kauss T, Lorenzato C, Gaubert A, Larivière M, Baillet J, Laroche-Traineau J, Jacobin-Valat MJ, Adumeau L, Mornet S, Barthélémy P, Duonor-Cérutti M, Clofent-Sanchez G, Crauste-Manciet S, (2017) “Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging » International Journal of Pharmaceutics, in press.


Carla A. H. Prata, Nathanel R. Luman, Yuan Li, Dan Luo, Thomas J. McIntosh, Philippe Barthélémy, and Mark W. Grinstaff. (2017) “Synthesis of Cationic Amphiphilic Surface-Block Dendrimers.” Journal of Inorganic and Organometallic Polymers and Materials, DOI 10.1007/s10904-017-0651-4


Maisani M, Ziane S, Ehret C, Levesque L, Siadous R, Le Meins JF, Chevalier P, Barthélémy P, De Oliveira H, Amédée J, Mantovani D, Chassande O. (2017) A new composite hydrogel combining the biological properties of collagen with the mechanical properties of a supramolecular scaffold for bone tissue engineering. J Tissue Eng Regen Med. doi: 10.1002/term.2569.


A. Ramin, K. R. Sindhu, A. Appavoo, K. Oumzil, M. W. Grinstaff, O. Chassande, P. Barthélémy (2017) “Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery” Adv. Mater. DOI: 10.1002/adma.201605227.


Karakia, S. Benizrie, R. Mejíasa, V. Baylota, N. Branger, T. Nguyen, B. Vialet, K. Oumzil, P. Barthélémy, P. Rocchi (2017) “Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer”, Journal of Controlled Release 258, 1–9


Latxague, A. Gaubert, D. Maleville, J. Baillet, M. Ramin, and P. Barthélémy (2016) “Carbamate based bolaamphiphile as Low Molecular Weight Hydrogelators”, Gels, 2, 25.


Jain, A. Karajic, M.Murawska, B. Goudeau, S. Bichon, S. Gounel, N. Mano, A. Kuhn, and P. Barthélémy (2016) “Low-Molecular-Weight Hydrogels as New Supramolecular Materials for Bioelectrochemical Interfaces” ACS Appl. Mater. Interfaces DOI: 10.1021/acsami.6b12890


Sybille Kenne, Ananda Appavoo, Jurgen Schulz, and Philippe Barthélémy (2016) “Nanoparticles for Radionuclide Imaging and Therapy: Principles” in Diagnostic and therapeutic nuclear medicine for neuroendocrine tumor, editors Karel Pacak and David Taïeb. Contemporary Endocrinology. ISBN 978-3-319-46036-9 ISBN 978-3-319-46038-3 (eBook)DOI 10.1007/978-3-319-46038-3


Ramin, J. Baillet, S. Benizri, L. Latxague, P. Barthélémy (2016) Uracile based Glycosyl-Nucleoside-lipids as low molecular weight organogelators, New Journal of chemistry, 40 (12)


Oumzil, M. A. Ramin, C. Lorenzato, A. Hemadou, J. Laroche, M. J. Jacobin-Valat, S. Mornet, C.-E. Roy, T. Kauss, K. Gaudin, G. Clofent-Sanchez, and P. Barthélémy (2016) “Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis.” Bioconjugate Chemistry 27 (3), pp. 569-575


A. Kaplan, P. Barthélémy and M. W. Grinstaff, Chem. Commun., (2016), “Self-assembled nanofiber hydrogels for mechanoresponsive therapeutic anti-TNFα antibody delivery” 52, pp. 5860-5863


Oumzil, K. ; Tonelli, G. ; Benizri, S. ; Staedel, C. ; Chaffanet, M. ; Navailles L. ; and Barthélémy, P. (2015) “pH triggable Nucleolipids via hydrolysis of their orthoester polar head” ChemMedChem, 10 (11), pp. 1797-1801


Patwa A. ; Thiéry, A. ; Lombard, F. ; Lilley, MKS.; Boisset, C. ; Bramar, JF. ; Bottero JY. ; and Barthélémy, P. (2015), “Accumulation of nanoparticles in jellyfish mucus: a bio-inspired route to decontamination of nano-waste” Nature Scientific Reports, 5, 11387


Latxague, L., Ramin, M.A., Appavoo, A., Berto, P., Maisani, M., Ehret, C., Chassande, O., and Barthélémy, P. (2015) “Controlling stem cell behavior by fine tuning the supramolecular assemblies of Low Molecular Weight Gelators.” Angewandte Chemie, 54 (15), pp. 4517-4521.


Patwa A. ; Labille, J. ; Bottero JY. ; Thiéry, A. ; and Barthélémy, P. (2015) “Decontamination of nanoparticles from aqueous samples using low molecular weight gels.” Chem. Commun. 51 (13), pp. 2547-255m


Roy, C.-E., Kauss, T., Prevot, S., Barthélémy, P., and Gaudin, K. (2015) “Investigation of fatty acid analysis by hydrophilic interaction liquid chromatography and charged aerosol detector.” J. Chrom. A, doi: 10.1016/j.chroma.2015.01.046


Camplo, M., Raimundo, J.-M., Navailles, L., Grinstaff, M.W., Barthélémy, P. (2014) “Bioinspired systems in supramolecular chemistry and nanotechnology-introducing the SupraBio themed issue.” New J. Chem., Volume 38, Issue 11, 1 Pages 5120-5121.


Oumzil, K. ; Khiati, S. ; Camplo M. ; Koquely M. ; Chuttani, K. ; Chaturvedi S. ; Mishra, KM. ; and Barthélémy P. ; (2014) “Nucleolipids as building blocks for the synthesis of 99mTc-labeled nanoparticles functionalized with folic acid.” New J. Chem., Volume 38, Issue 11, 1, Pages 5240-5246.


Patwa, A. ; Gissot, A. ; Oumzil, K. ; and Barthélémy P. (2014) “Lipid Oligonucleotide Bioconjugates: Applications in medicinal chemistry” in DNA in Supramolecular Chemistry and Nanotechnology, ed. E. Stulz and G. Clever, John Wiley & Sons Ltd., in print.


Barthélémy P. “Qu’est ce que le vivant; matières inanimées avez-vous donc une âme ?” in Elohi-Peuples indigènes et environnement, biannual review, PUB (Presse Universitaire de Bordeaux). (2014), vol 5/6, p 27-37.


Gissot, A. ; Oumzil, K. ; Patwa, A. ; and Barthélémy P. ; (2014) A hybrid lipid oligonucleotide: a versatile tool for supramolecular chemistry. New J. Chem., Volume 38, Issue 11, 1, Pages 5129-5134.


Thanassoulas, A.; Barthélémy, P.; Navailles, L.; Sigaud, G. (2014) From Nucleobases to Nucleolipids: An ITC Approach on the Thermodynamics of Their Interactions in Aqueous Solutions. Phys. Chem., 118(24):6570-85


Saez G., Aye M., De Meo M., Aimé A., Bestel I., Barthélémy P., Di Giorgio C. (2014) Genotoxic and oxidative responses in coelomocytes of Eisenia fetida and Hediste diversicolor exposed to lipid-coated CdSe/ZnS quantum dots and CdCl2. Environ Toxicol. doi: 10.1002/tox.21966.


Luvino, D. ; Khiati, S. ; Oumzil, K. ; Rocchi, P. ; Camplo, M. ; and Barthélémy P. (2013) Efficient delivery of therapeutic small nucleic acids to prostate cancer cells using ketal nucleoside lipid nanoparticles. J. Control. Release, 172, 954–961


Latxague L, Patwa A, Amigues E, Barthélémy P. (2013) Glycosyl-nucleolipids as new bioinspired amphiphiles. Molecules, 18(10):12241-63.


Patwa A, Salgado G, Dole F, Navailles L, Barthélémy P. (2013) Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids” Org. Biomol. Chem. 11(41):7108-12. doi: 10.1039/c3ob41707g.


Aimé A, Beztsinna N, Patwa A, Pokolenko A, Bestel I, Barthélémy P. (2013) Quantum Dot Lipid Oligonucleotide Bioconjugates: Toward a New Anti-MicroRNA Nanoplatform. Bioconjugate Chem., 24 (8), pp 1345–1355


Pokholenko, O., Gissot, A., Vialet, B., Bathany, K., Thiéry, A., and Barthélémy P. (2013) Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery. Mater. Chem. B, DOI: 10.1039/c3tb20357c.


Tonelli, G.; Oumzil, K.; Nallet, F.; Gaillard, C.; Navailles, L.; and Barthélémy P. (2013) Amino Acid–Nucleotide–Lipids: Effect of Amino Acid on the Self-Assembly Properties. Langmuir, 29 (18), pp 5547–5555.


Aye M, Di Giorgio C, Mekaouche M, Steinberg JG, Brerro-Saby C, Barthélémy P, De Méo M, Jammes Y. (2013) Genotoxicity of intraperitoneal injection of lipoamphiphile CdSe/ZnS quantum dots in rats. Mutat Res. 758(1-2):48-55. doi:pii: S1383-5718(13)00263-5.


Aye M, Di Giorgio C, Berque-Bestel I, Aime A, Pichon BP, Jammes Y, Barthélémy P, De Méo M. (2013) Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots. Mutat Res. 750(1-2):129-38.doi: 10.1016/j.


Taïb, N.; Aimé, A.; Moreau, L.; Camplo M.; Houmadi, S.; Desbat B.; Laguerre M.; Grinstaff, M.; Bestel I. and Barthélémy P. (2012) Formation of Supramolecular Systems via Directed Nucleoside-lipid Récognition. J. Colloid Interface Science, 1;377(1):122-30.


Lamanna, C.; Lusic, H.; Camplo, M.; McIntosh, T.; Barthélémy, P.; Grinstaff, M., (2012) Charge-reversal Lipids, Peptide-based Lipids, and Nucleoside-based Lipids for Gene Delivery. Accounts of Chemical Research, DOI: 10.1021/ar200228y


Desbat, B.; Arazam, N.; Khiati, S.; Tonelli, G.; Neri, W.; Barthélémy, P.; Navailles, L., (2012) Unexpected bilayer formation in Langmuir films of nucleolipids. Langmuir, 1;28(17):6816-25.


Taïb, N.; Aimé, A.; Houmadi, S.; Castano, S.; Barthélémy, P.; Laguerre, M.; Bestel, I.; (2012) Interactions of Nucleolipids with Oligonucleotides: molecular modelling and physicochemical studies. Langmuir, 15;28(19):7452-60.


Ziane S, Schlaubitz S, Miraux S, Patwa A, Lalande C, Bilem I, Lepreux S, Rousseau B, Le Meins JF, Latxague L, Barthélémy P, Chassande O. (2012) A thermosensitive low molecular weight hydrogel as scaffold for tissue engineering. Eur Cell Mater. 23;23: 147-60


Dolain, C., Patwa, A., Godeau, G., Barthélémy, P. (2012) “Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications.” Appl. Sci. 2, 245-259.


Latxague, L., Dalila, M.J., Patwa, A. Sophia, Z., Chassande, O., Godeau, G. and Barthélémy P. (2012) Glycoside nucleoside lipids (GNLs): An intrusion into the glycolipids’ world? C.R. Chimie, 15, 29–36


Thiéry, L. De Jong, J. Issartel, X. Moreau, G. Saez, P. Barthélémy, I. Bestel, C. Santaella, W. Achouak, M. Auffan, J. Rose and J-Y. Bottero (2012) Effects of metallic and metal oxide nanoparticles in aquatic and terrestrial food chains. Biomarkers responses in invertebrates and bacteria. Int. J. Nanotechnol., Vol. 9, No.3/4/5/6/7 pp. 181 – 203


Céballos, C., Khiati, S., Barthélémy, P. and Camplo M. (2012) Acyclic anionic nucleolipids for DNA delivery. Nanosci. Lett., 2: 20.


Latxague, L., Sophia, Z., Chassande, O., Patwa, A., L., Dalila, M.J., and Barthélémy P. (2011) Glycosylated nucleoside lipid promotes the liposome internalization in stem cells. Chem. Commun., 47, 12598–12600


Khiati, S., Luvino, D., Oumzil, K., Chauffert, B., Camplo, M. and Barthélémy P. (2011) Nucleoside Lipid-Based Nanoparticles for Cisplatin Delivery. ACS Nano, 5 (11), pp 8649–8655.


Patwa, A., Gissot, A., Bestel, I. and Barthélémy, P. (2011) Hybrid lipid oligonucleotide conjugates: synthesis, self-assemblies and biomedical applications. Chem. Soc. Reviews, 40, 5844–5854.


Zhang, X.-X., Prata, C., Berlin, A. J., McIntosh, T., Barthélémy, P. and Grinstaff, M. (2011) Synthesis, Characterization, and In Vitro Transfection Activity of Charge-Reversal Amphiphiles for DNA Delivery. Bioconjug. Chem., 22, 690–699.


Oumzil, K., Khiati, S., Grinstaff, M. W., and Barthélémy, P. (2011) Reduction-triggered delivery using nucleoside-lipid based carriers possessing a cleavable PEG coating. J. Control. Release, doi:10.1016/j.jconrel.2011.02.008


Zhang, X.X., Prata, C.A., McIntosh, T.J., Barthélémy, P., Grinstaff, M.W. (2010) The effect of charge-reversal amphiphile spacer composition on DNA and siRNA delivery. Bioconjug. Chem. 21, 988-993.


Godeau, G., Arnion, H., Brun, C., Staedel, C. and Barthélémy, P. (2010) Fluorocarbon oligonucleotide conjugates for nucleic acids delivery. Med. Chem. Commun., 1, 76–78


Saez, G., Moreau, X., De Jong, L., Thiéry, A., Dolain, C., Bestel, I., Di Giorgio, C., De Meo, M., Barthélémy, P. (2010) Development of new nano-tools: Towards an integrative approach to address the societal question of nanotechnology? Nano Today 5, 251-253.


Ceballos, C., Khiati, S., Prata, C.A., Zhang, X.X., Giorgio, S., Marsal, P., Grinstaff, M.W., Barthelemy, P., Camplo, M. (2010) Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection. Bioconjug. Chem. 21, 1062-1069.


Godeau, G., Brun C., Arnion, H., Staedel, C., Barthélémy, P. (2010) “Glycosyl-nucleoside fluorinated amphiphiles as components of nanostructured hydrogels” Tetrahedron Letters, (51), 1012-1015


Khiati, S., Pierre, N., Andriamanarivo, S., Grinstaff, M.W., Arazam, N., Nallet, F., Navailles, L., Barthélémy, P. (2009) Anionic nucleotide-lipids for in vitro DNA transfection. Bioconjug. Chem. (20), 1765-1772.


Godeau, G., Bernard, J., Staedel, C., Barthélémy, P. (2009) Glycosyl-nucleoside -lipid based supramolecular assembly as a nanostructured material with nucleic acid delivery capabilities. Chem. Commun., 5127-5129.


Barthélémy, P. (2009) Nucleoside-based lipids at work: From supramolecular assemblies to biological applications. Comptes Rendus Chimie 12, 171-179.


Godeau G. and Barthélémy P. (2009) Glycosyl-Nucleoside-Lipids as Low Molecular Weight Gelators. Langmuir, 25, 8447-8450.


Ceballos, C.; Prata, C. A. H.; Payet, D; Giorgio, S.; Garzino, F.; Barthélémy, P.; Grinstaff, M. W.; and Camplo, M. (2009) Cationic Nucleoside Lipids Based on a 3-Nitropyrrole Universal Base for siRNA Delivery. Bioconjug Chem, 20, 193-196.


Moreau, L.; Camplo, M.; Wathier, M.; Taib, N.; Laguerre, M.; Bestel, I.; Grinstaff, M. W.; Barthélémy, P., (2008) Real time imaging of supramolecular assembly formation via programmed nucleolipid recognition. J. Am. Chem. Soc., 130, (44), 14454-5.


Gissot, A.; Di Primo, C.; Bestel, I.; Giannone, G.; Chapuis, H.; Barthelemy, P., (2008) Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch. Chem. Commun., (43), 5550-2.


Godeau, G.; Staedel, C.; Barthélémy, P., (2008) Lipid-conjugated oligonucleotides via “click chemistry” efficiently inhibit hepatitis C virus translation. Journal of Medicinal Chemistry, 51, (15), 4374.


Chapuis, H., Bui, L., Bestel, I., Barthélémy, P., (2008) 2’-Lipid-modified oligonucleotides via a ‘Staudinger-Vilarrasa’ reaction. Tetrahedron Letters, 49, (48), 6838.


Gissot, A., Camplo, M., Grinstaff, M. W., Barthélémy, P., (2008) Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids. Org Biomol Chem, 6, (8), 1324-33.


De Jong, L.; Moreau, X.; Thiery, A.; Godeau, G.; Grinstaff, M. W.; Barthélémy, P., (2008) Amphiphilic copolymer for delivery of xenobiotics: in vivo studies in a freshwater invertebrate, a Mesostominae flatworm. Bioconjug Chem, 19, (4), 891-8.


Prata, C. A. H.; Li, Y.; Luo, D.; McIntosh, T. J.; Barthelemy, P.; Grinstaff, M. W., (2008) A new helper phospholipid for gene delivery. Chem. Commun., (13), 1566.


Prata, C. A.; Zhang, X. X.; Luo, D.; McIntosh, T. J.; Barthelemy, P.; Grinstaff, M. W., (2008) Lipophilic peptides for gene delivery. Bioconjug Chem, 19, (2), 418-20.


Bestel, I.; Campins, N.; Marchenko, A.; Fichou, D.; Grinstaff, M. W.; Barthelemy, P., (2008) Two-dimensional self-assembly and complementary base-pairing between amphiphile nucleotides on graphite. J. Colloid Interface Sci, 323, (2), 435-40.



Barthélémy, P.; Gissot, A; Vialet, B. (2017) «Tetramolecular parallel G-quadruplex-forming hydrophobically modified oligonucleotides». EP Patent EP17 305 651.6.


Rocchi, P.;Cherif, C.; Benizri, S.; Barthélémy, P.; El Kaoutari, A. (2016) Antisense Oligonucleotides effective to reduce the expression of menin in cancer cells of a subject – EP Patent EP16 305 135.2


Barthélémy, P.; Oumzil K. (2015) “pH sensitive linkers”. EP Patent EP15305778.


Barthélémy, P.; Oumzil K.; Clofent-Sanchez G.; Jacobin Valat, MJ.; Laroche; J.; Mornet S.; Gaudin K. (2015) “Lipid based nanovehicles loaded with nanoparticles and therapeutic agent for imaging guided therapy ”. EP Patent EP15305592


Barthélémy, P.; Ramin M.; Latxague L.; Appavoo A.; Chassande O. Erhret C. “Glycosylated nucleo bolaamphiphlile as new LMWG for biomedical applications. (2014) 6th Oct. : EP14290302.0


Barthélémy, P., Rocchi, P., Gissot, A., P. Oumzil, K., Acunzo, J., (2013) Hydrophobically modified antisense oligonucleotides comprising a triple alkyl chain. patent n° PCT/IB2013/001516.


Barthélémy, P., Rocchi, P., P. Oumzil, K., Acunzo, J. (2013) Hydrophobically modified antisense oligonucleotides comprising a cetal group. n° PCT/IB2013/001517.


Barthélémy, P. ; Thiéry, A. ; Patwa, A. (2012) Decontamination par hydrogels d’echantillon aqueux contenant des nanoparticules, French patent 25-01-2012, n°12/00233.


Barthélémy, P. ; Khiati S. ; Camplo, M. (2009) Formulations à compartiment multiples à base de molécules ou macromolécules amphiphiles fonctionnelles”. French patent N° INPI 09/02607 du 29/05/2009.


Barthélémy, P. ; Camplo, M. ; Campins, N. ; Chauffert, B. ; Bouyer, F Nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation. French patent N° INPI 07/08399 du 30/11/2007. Extention PCT PCT/FR2008/001661