The development of artificial materials for repairing, replacing or regenerating damaged tissues remains an important issue in the field of regenerative medicine. These materials mimic natural extracellular matrix (ECM), which can be seen, as a soft matter constituted of extracellular molecules such as proteins or polysaccharides secreted by the cells. Recent studies in these promising fields have focused on understanding how the physicochemical parameters can control stem cell fate. We are interested in developping new supramolecular materials (gels…) suitable for stem cell cultures, tissue engineering and/or bioprinting.
Bioprinting using biocompatible hydrogels
we report on a new generation of low molecular weight gels (LMWG) for the culture of isolated stem cells. The bola-amphiphile structures derived from nucleolipids feature unique rheological and biological properties suitable for tissue engineering applications.
Latxague, L., Ramin, M.A., Appavoo, A., Berto, P., Maisani, M., Ehret, C., Chassande, O., and Barthélémy, P. (2015) Angewandte Chemie, 54 (15), pp. 4517-4521.