Surname / Name: Geoffrey Prévot, Ph.D student.
Thesis director: Pr. Sylvie Crauste-Manciet
Atherosclerosis is a chronic vascular disease, affecting medium and large-sized arteries with a multifocal development of so-called atheroma plaques characterized by an excessive build-up of lipid and immune cells in the artery wall. The pathology evolves over decades leading to dramatic events such as Acute Coronary Syndromes (ACS) due to the rupture of vulnerable plaques. Nowadays atherosclerosis diagnosis is based on family history, physical examination and/or blood test to check levels of fats, cholesterol, sugar, and proteins. For high-risk population, X-ray angiography remains the everyday clinical practice but this imaging method only gives information about luminal stenosis and fail to define accurately the severity of coronary atherosclerosis.
Thus, this complex and multifactorial disease could benefit from new imaging approaches to provide detail on plaque composition and molecular activity. My thesis focuses on engineered oil-in-water nanoemulsion formulation loaded with iron oxide particles and grafted with atheroma specific antibodies as a new tool for atherosclerosis targeting and imaging.
This project is funded by TRAIL LabEx a program that exploit the multidisciplinarity and the translational forces of Bordeaux imaging community.
Since 2015 – Ph.D student in Chemistry/Biology interface, University of Bordeaux, France
2015 – Master’s degree in Biochemistry (Chemistry, Molecular and Structural Biology), University of Bordeaux, France
2013 – Bachelor’s degree in Biochemistry, University of Bordeaux, France
Internship and work experiences
2015 Nanomedicine Internship – ICMCB, Pessac, France
7 months Supervisors: Dr. Stephane Mornet, Pr. Alain Brisson
Development of magnetic nanoparticles biofunctionalized with Annexin-A5 to isolate, concentrate and purify disease markers from blood sample under a magnetic field.
2014 Nanomedicine Internship – ICMCB, Pessac, France
3 months Supervisor: Dr. Stephane Mornet
Development of strategies to graft a protein named Annexin-A5 to magnetic particles’ surface.
2012 Ecotoxicology Internship – Arkema, Lacq, France
1 month Supervisor: Dr. Christian Gancet
Ecotoxicity characterization of oils and rubber chemicals on freshwater microalgae growth and on planktonic crustaceans’ reproduction according to ISO and OECD guidelines [Test No. 201 and 211].