Valérie Desvergnes
CR CNRS
accreditation to supervise research

Surname / Name: Valérie DESVERGNES Ph.D, CNRS researcher.

Email: valerie.desvergnes@u-bordeaux.fr

Career history. Valérie Desvergnes received her doctorate in chemistry from the University of Lyon 1, France in 1999. She was a postdoctoral fellow at the Research Institute on Catalysis for few months and then joined the group of Pr Jérome Lacour (Fondation Sandoz Grant) for 20 months. In 2002, she was appointed CNRS researcher at the Institute of Organic and Analytic Chemistry (ICOA) at the University of Orléans. Her research topic was the design, synthesis and biological evaluation of innovative iminosugars and iminosugar nucleotides as antimicobacterial compounds. In 2007 she moved to Bordeaux and developed new synthetic methodology using silicon tools and their application in total synthesis (team of Pr. Yannick Landais at the Institute of Molecular Sciences (ISM)) In 2016, she joined ChemBioPharm (leader: Pr. Philippe Barthélémy) to develop new biomimetic organocatalyzed synthetic pathways to nucleoconjugates (nucleolipids, glyconucleolipids etc …). She is author or co-author of 35 publications and one patent (h-factor 19).

Education

PhD. in Chemistry, University of Lyon I, France.

Habilitation à Diriger les Recherches (HDR)

Expertise

– Expert ANR, Region Rhône-Alpes, Europe …

– Reviewer for Organic Letters, Journal of Organic Chemistry (ACS), Tetrahedron Letters (Elsevier), etc.

Research. Valérie Desvergnes is interested in the development of “biomolecule-friendly” synthetic methods. In the field of bio-inspired amphiphiles, she applies biocompatible organocatalyzed Stetter reaction to nucleosides substrates and her efforts are devoted to make this reaction efficient under aqueous conditions. She also wants to develop the use of organocatalysis in the field of bioconjugation and DNA assisted synthesis. She is interested in the design and synthesis of new nucleoconjugates (lipophilic nucleolipids, supramolecular biomaterials…) and in their potential biomedical applications in the field of drug delivery. She was involved in several national and international projects (ANR, CEFIPRA, Region Aquitaine, Marie Curie …)

Publications since 2016

Stereocontrolled (Me3Si)3SiH-Mediated Radical and Ionic Hydride Transfer in Synthesis of 2,3,5-Trisubstituted THF

Grelaud, S.; Desvergnes, V.; Landais, Y. Org. Lett., 2016, 18, 1542-1545. (IP: 6.73)

https://doi.org/10.1021/acs.orglett.6b00303

Lipid and nucleic acid chemistries: combining the best of both worlds to construct advanced materials

Baillet, J.; Desvergnes, V.; Hamoud, A.; Latxague, L.; Barthélémy, P. Advanced Materials, Adv. Mater. 2018, 30, 1705078 (IP: 19.79)

https://doi.org/10.1002/adma.201705078

An organocatalyzed Stetter reaction as a bioinspired tool for the synthesis of nucleic acid based bioconjugates” Hamoud, A.; Barthélémy, P.; Desvergnes, V. Org. Biomol. Chem. 2018, 16, 1760-1769. (IP 3.49)

https://doi.org/10.1039/C8OB00192H

Cytidine and guanine based nucleotide-lipids”

Alies, B.; Ouelhazi, M. A.; Patwa, A.; Verget, J.; Navailles, L.; Desvergnes, V.;  Barthélémy, P. Org. Biomol. Chem. 2018, 16, 4888-4894. (IP 3.49)

https://doi.org/10.1039/C8OB01023D

An Approach toward the Synthesis of the Spiroimine Fragment of 13-Desmethylspirolide C and Gymnodimine A”

Guthertz, A; Lusseau, J.; Desvergnes, V.; Massip, S.; Landais, Y. Chem. Eur. J., 2019, 25, 1553-1560. (IP 5.16)

https://doi.org/10.1002/chem.201804972

Synthesis and Intracellular uptake of Rhodamine-nucleolipid conjugates into a nanoemulsion vehicle

Cunha, A; Prévot, G.; Mousli, Y.; Barthélémy, P.; Crauste-Manciet, S.; Dehay, B. and Desvergnes, V. ACS Omega , 2020, 5,  5815-5823 DOI : 10.1021/acsomega.9b03992

Debiais, M.: Hamoud, A.;  Drain, R.;  Barthélémy, P. and  Desvergnes, V.  Bio-inspired NHC-organocatalyzed Stetter reaction
in aqueous conditions. RSC Adv., 2020, 10, 40709–40718. DOI: 10.1039/D0RA08326G

Patents

FR 19 09789 : Procédé de synthèse utilisant des carbènes en milieu aqueux et appliqué aux biomolécules.

Megane Debiais, Aladin Hamoud, Philippe Barthélémy, Valérie Desvergnes (Inventeur principal)

FR 19 09789.

Extension Internationale 4/09/2020: PCT/EP2020/074787.